Glutathione deficiency

I suspect that glutathione (GSH) deficiency is relatively common in modern society. Although the body will create GSH, it needs the sulphur-containing amino acid cysteine in order to do so. Unfortunately, sulphur intake, including cysteine, tends to be fairly low with modern diets. Since GSH is involved with many detoxification reactions, it also gets consumed much more quickly now than in the past, given our regular exposure to things like pesticides.

In addition, in order for GSH to be used properly by the body, the mineral selenium (Se) is required. Se is present in GSH peroxidase, one function of which is to eliminate peroxides such as hydrogen peroxide. Se is also often low in the diet, particularly in certain regions with soils that are naturally low in Se, such as Finland and New Zealand. Low levels of Se in the blood are a well-documented risk factor for cancer.

Just because the chemical pathways exist in the body doesn’t mean that nutrients or their co-factors are being made in the quantity needed. Also, supplementation of the substance itself (such as GSH, which is largely destroyed in the stomach) is often not the best way to address the problem; specific precursors such as cysteine or Se may be much more effective. Getting these precursors through diet is the ideal for the long-term, diet alone may not be enough to correct or even prevent deficiencies (depending on where you live and the source and quality of your food).